In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22536-66-9, name is 2-Chloropyrimidine-4-carboxamide, the common compound, a new synthetic route is introduced below. Quality Control of 2-Chloropyrimidine-4-carboxamide
A mixture of 3-{[2-amino-6-(3-chloro-2-methylphenyl) pyrimidin-4-yl]ami no}propan1-01 (intermediate 24), 2-chloropyrimidine-4-carboxamide (1.1 equiv.) and 0s2003(2.0 equiv.) in DMSO was heated in a sealed tube at 90C for 2 h. After coolingwas methanol added to the solution, followed by filtration and purification by preparative LC to furnish the title compound. LCMS [M+H]414. 1H NMR (400MHz, METHANOL-d4) oe ppm 8.79 (d, J=5.1 Hz, 1 H), 7.69 (s, 1 H), 7.55 – 7.63(m, 1 H), 7.30 – 7.41 (m, 3 H), 6.04 (s, 1 H), 4.59 (t, J=6.0 Hz, 2 H), 3.76 (t, J=6.8Hz, 2 H), 2.18 (quin, J=6.3 Hz, 3 H).
The synthetic route of 22536-66-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; WALLNER, Olov; KOOLMEISTER, Tobias; VALLIN, Karl Sven Axel; HENRIKSSON, Carl Martin; JACQUES, Sylvain; HOMAN, Evert; HELLEDAY, Thomas; WO2015/187088; (2015); A1;,
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