Adding a certain compound to certain chemical reactions, such as: 2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2380-63-4, blongs to pyrimidines compound. 2380-63-4
NIS(1.1eq, 4.95 g, 22 mmol) was slowly added into the mixture of 9(1eq, 2.70 g, 20 mmol) and DMF (50 mL) at r.t. The reaction mixturewas continued stirred at r.t. overnight. The solvent was removed invacuo and water was added. The mixture was subjected to sonicationfor 10 min. The precipitate was collected by filtration, rinsedwith water, and dried. The solid 10 was used for the next stepwithout further purification (5.01 g, 96% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2380-63-4, its application will become more common.
Reference:
Article; He, Linhong; Pei, Heying; Zhang, Chufeng; Shao, Mingfeng; Li, Dan; Tang, Mingli; Wang, Taijing; Chen, Xiaoxin; Xiang, Mingli; Chen, Lijuan; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 96 – 112;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia