Synthetic Route of 163263-91-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.163263-91-0, name is 2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine, molecular formula is C11H8Cl2N2O, molecular weight is 255.1, as common compound, the synthetic route is as follows.
In a sealed tube, suspension of 1a (60 mg, 0.235 mmol) in liq. ammonia (9 ml) and ethanol (1 ml) was heated to 110 C for 4-5 h. Reaction was monitored by TLC. Solvent was distilled off under vacuum to give crude product. Crude product was purified by silica gel column chromatography using methanol/chloroform as eluent to give 1b (12 mg, 23.57%). Mp 210-212 C; 1H NMR (DMSO-d6, 300 MHz): delta 3.82 (s, 3H, OCH3), 6.20 (s, 1H, Ar), 6.55 (broad s, 2H, NH2), 6.98 (broad s, 2H, NH2), 7.04 d, 2H, J = 8.7 Hz, Ar), 7.81 (d, 2H, J = 8.7 Hz, Ar); MS (ESI+) m/z 217 (M+H)+.
The chemical industry reduces the impact on the environment during synthesis 163263-91-0, I believe this compound will play a more active role in future production and life.
Reference:
Article; B-Rao, Chandrika; Kulkarni-Almeida, Asha; Katkar, Kamlesh V.; Khanna, Smriti; Ghosh, Usha; Keche, Ashish; Shah, Pranay; Srivastava, Ankita; Korde, Vaidehi; Nemmani, Kumar V.S.; Deshmukh, Nitin J.; Dixit, Amol; Brahma, Manoja K.; Bahirat, Umakant; Doshi, Lalit; Sharma, Rajiv; Sivaramakrishnan; Bioorganic and Medicinal Chemistry; vol. 20; 9; (2012); p. 2930 – 2939;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia