Application of 50270-27-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50270-27-4, name is 2,4,6-Trichloropyrimidine-5-carbaldehyde, molecular formula is C5HCl3N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To 2,4,6-trichloropyrimidine-5-carbaldehyde (0.693 g, 3.27 mmol) in EtOH (10 mL) at -78 °C under argon was added (tetrahydro-2H-pyran-4- yl)hydrazine hydrochloride (0.5 g, 3.27 mmol) followed by dropwise addition of TEA (2.05 mL, 14.7 mmol). The mixture was stirred at -78 °C for 1 h, then at 0 °C for 2 h. The mixture was then concentrated under reduced pressure onto Celite and purified by silica gel chromatography eluting with DCM to afford 4,6-dichloro-l-(tetrahydro-2H- pyran-4-yl)-lH-pyrazolo[3,4-d]pyrimidine (440 mg, 49percent). LCMS (ESI) m/z 273 (M + H)+.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 50270-27-4, 2,4,6-Trichloropyrimidine-5-carbaldehyde.
Reference:
Patent; AMBIT BIOSCIENCES CORPORATION; CHAO, Qi; HADD, Michael, J.; HOLLADAY, Mark, W.; ROWBOTTOM, Martin; WO2012/30924; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia