The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32998-03-1, name is 2,6-Dichloro-N-methylpyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. name: 2,6-Dichloro-N-methylpyrimidin-4-amine
EXAMPLE 42 N-Methyl-2,6-di-(4′-t-butoxycarbonyl-1′-piperazinyl)-4-pyrimidinamine (V) A mixture of 2,6-dichloro-4-methylaminopyrimidine (III, EXAMPLE 1, 5 g) dissolved in o-xylene (300 ml) is treated with mono-t-BOC-piperazine (IV, 20.92 g) and the reaction mixture is refluxed for 50 hr. The reaction mixture is concentrated under reduced pressure. The resulting residue is partitioned between chloroform and saturated sodium bicarbonate. The organic layer is separated, washed with saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product (24.53 g) is chromatographed on silica gel (590 g). The column is packed and eluted with chloroform/acetone (97/3). An initial fraction of 400 ml is collected followed by 8 ml fractions. Based on their TLC homogeneity, fractions 132-326 are combined and concentrated to give the title compound, NMR (CDCl3, TMS) 4.94, 4.96, 3.75-3.65, 3.55-3.4, 2.85 and 1.48 8; MS (m/z) M+ (found) 477, other ions at m/z 420, 376, 364, 348, 321,265, 221, 178, 164 and 57.
With the rapid development of chemical substances, we look forward to future research findings about 32998-03-1.
Reference:
Patent; The Upjohn Company; US5502187; (1996); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia