Electric Literature of 59864-30-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59864-30-1, name is 2,6-Dimethoxypyrimidine-4-carboxylic acid, molecular formula is C7H8N2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 43 Preparation of (S)-3-[(2,6-dimethoxy-pyrimidine-4-carbonyl)-amino]-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid (S)-3-amino-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid methyl ester (HCl salt) (100 mg, 0.23 mmol) was dissolved in DMF (2.5 ml) and the following reagents were successively added at rt: 2,6-dimetoxy-pyrimidine-4-carboxylic acid (47 mg, 0.26 mmol), triethylamine (0.10 ml, 0.70 mmol), HOBT (38 mg, 0.28 mmol), and HBTU (110 mg, 0.28 mmol). The mixture was stirred at rt for 1 h, then quenched with 1N HCl and extracted with EtOAc. The layers were separated. The organic layer was successively washed with water and brine, then dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by flash chromatography with 50-100% EtOAc in hexane to afford the desired methyl ester (60 mg, 46% yield). This ester was dissolved in THF/water (2 ml/1 ml) and treated with LiOH.H2O (44 mg, 1.0 mmol) at 40 C. for 40 min. The mixture was quenched with 1N HCl and concentrated. The crude was purified by reverse phase HPLC to afford the desired product (39 mg, 72% yield). MS m/e 544.0 (M+H+).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59864-30-1, 2,6-Dimethoxypyrimidine-4-carboxylic acid.
Reference:
Patent; Gillespie, Paul; Michoud, Christophe; Rupert, Kenneth Carey; Thakkar, Kshitij Chhabilbhai; US2012/238569; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia