Electric Literature of 289042-12-2, Adding some certain compound to certain chemical reactions, such as: 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate,molecular formula is C29H40FN3O6S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 289042-12-2.
3 g of the compound prepared in Example 1 is dissolved in 30 ml of ACN at room temperature, and then 9 ml of 1N HCl is added. The reaction is completed by stirring at room temperature for 8 hours.The reaction was cooled and maintained at 0 C,Add 0.9 g 10% aqueous NaOH solution.The reaction is allowed to warm to room temperature and then stirred for 4 hours to complete the reaction. Water is added to quench the reaction and then 3 mL of 1N HCl is slowly added dropwise to bring the pH to 8.0. The aqueous layer was washed with methylene chloride to separate the aqueous layerdo. 2.7 g of CaCl2 was added thereto, followed by stirring at room temperature for about 30 minutes. The reaction solution is kept below 15 C to produce a solid and then filtered.After washing with water, suvastatin was dried under reduced pressure to obtain 2.6 g of a calcium salt of a white solid.
According to the analysis of related databases, 289042-12-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; WELL ENC CO., LTD; GO, SUNG HWAN; KIM, GYUNG IR; GO, YOUNG LI; PARK, YONG MUK; JUNG, HUN HWEE; (18 pag.)KR101566536; (2015); B1;,
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