Adding a certain compound to certain chemical reactions, such as: 29274-24-6, 5-Chloropyrazolo[1,5-a]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 29274-24-6, blongs to pyrimidines compound. Application In Synthesis of 5-Chloropyrazolo[1,5-a]pyrimidine
5-Chloropyrazolo[l,5-a]pyri midine (500mg, 3.25mmol) taken up in 3ml acetonitrile and 1.5ml water. 2-isopropoxy-4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyridine (lg, 3.9m mol), Potassiu m carbonate (902mg, 6.5m mol), and Pd(dppf)Cl2:DCM (267mg, 0.325m mol) added and reaction stirred in microwave in a sealed tube at 120 C for 12 minutes. Reaction cooled filtered through celite washed through with ethyl acetate and reduced in vacuo. Reaction taken up in 1:1 ethyl acetate: hexane and filtered through a plug of celite. The filtrate was ollected, dried in vacuo to obtain 740 mg of crude product to be used as is in next step. LRMS (ESI) m/z 255 [(M+H)]+, calc’d for C14H14N4O: 254.2.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,29274-24-6, its application will become more common.
Reference:
Patent; LEXICON PHARMACEUTICALS, INC.; BI, Yingzhi; GARDYAN, Michael Walter; GREEN, Michael Green; KUMI, Godwin; ZHANG, Yulian; WO2015/35117; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia