With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.83255-86-1, name is 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine, molecular formula is C5H4BrN5, molecular weight is 214.02, as common compound, the synthetic route is as follows.HPLC of Formula: C5H4BrN5
Intermediate 5 (2 g, 9.34 mmol), 4-phenoxyphenylboronic acid (4 g, 18.69 mmol),Pd(PPh3)4 (531 mg, 0.46 mmol), K3PO4.3H2O (7.45 g, 28.02 mmol),Add into a 250 ml two-necked flask and add 100 ml of solvent 1,4-dioxane: water = 4:1 (v/v) to dissolve.Nitrogen protection, ultrasonically removes oxygen from the solution, and replaces the air in the device with nitrogen.The oil was heated to reflux in a 135 C oil bath, and the reaction was completed after TLC detection for 30 h.The reaction mixture was cooled to room temperature, filtered over Celite, and evaporated.Obtained a pale yellow solid of 2.23 g, a yield of 78.8%.The elution system was dichloromethane: methanol = 100:1.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,83255-86-1, 3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine, and friends who are interested can also refer to it.
Reference:
Patent; Shandong University; Zhao Guisen; Ran Fansheng; Liu Meixia; Liu Yang; Wang Luhua; (48 pag.)CN109369654; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia