Application of 33034-67-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.33034-67-2, name is 2-Chloro-4-(trifluoromethyl)pyrimidine, molecular formula is C5H2ClF3N2, molecular weight is 182.531, as common compound, the synthetic route is as follows.
Step 4: The product of Step 3 (460 mg, 1.720 mmol), 2-chloro-4-(trifluoromethyl)pyrimidine (314 mg, 1.638 mmol), Xantphos (284 mg, 0.492 mmol), palladium (II) acetate (73.6 mg, 0.328 mmol), cesium carbonate (1.068 g, 3.28 mmol) and dioxane (12.3 mL) were heated at 90 ¡ãC for 90 minutes. The reaction mixture was diluted with ethyl acetate, washed with water and dried over Na2S04. Filtration and solvent evaporation gave a residue which was further purified by column chromatography on silica gel, eluting with 40percent ethyl acetate in hexane to afford l-[5-(3- cMoro-5-{[4-(trifluoromemyl)pyrimidin-2-yl^ as a brown solid (390 mg, 55.8percent). NM (500 MHz, CDCI3): 5 8.71 (d, J – 4.7 Hz, 1 H); 7.92(s, 1 H); 7.85 (s, 1 H); 7.78 (s, 1 H); 7.69 (s, 1 H); 7.25 (s, 1 H); 7.13 (d, J= 4.8 Hz, 1 H); 3.81 (s, 1 H); 2.73 (s, 2 H); 2.58-2.47 (m, 2 H); 2.13-1.97 (m, 2 H) MS APCI: [M+H]+ m/z 427.1. rhSYK activity = ++
The chemical industry reduces the impact on the environment during synthesis 33034-67-2, I believe this compound will play a more active role in future production and life.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia