3740-92-9 , The common heterocyclic compound, 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine, molecular formula is C10H6Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Under a nitrogen atmosphere, (10 g, 50 mmol) of compound 7-24-5 and (6.1 g, 50 mmol) of compound 9-12-6,(3.5 g, 3 mmol) tetrakis (triphenylphosphine) palladium, (3.2 g, 10 mmol) tetrabutylammonium bromide, (2 g, 50 mmol) sodium hydroxide,(15mL) water and (100mL) toluene were added to a 250mL three-necked flask, and the reaction was heated at 80 C with stirring for 12 hours.Most of the solvent was removed by rotary evaporation of the reaction solution, washed three times with dichloromethane and washed with water. The organic liquid was collected and mixed with silica gel.The yield is 80%
According to the analysis of related databases, 3740-92-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Guangzhou Huarui Optoelectric Materials Co., Ltd.; He Ruifeng; Lin Weijie; Wu Canjie; Pan Junyou; (40 pag.)CN109970660; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia