As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H15BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 4-(4-Bromophenyl)-2,6-diphenylpyrimidine
Under a nitrogen atmosphere 2- (4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) phenyl) -1,10-phenanthroline (5.0 g, 13.08 mmol) 4- (4-bromophenyl) -2,6-diphenylpyrimidine (6.10 g, 15.96 mmol), tetrakis-triphenylphosphine palladium (0) (Pd (PPh3) 4) (0.75 g, 0.65 mmol) 4M potassium carbonate aqueous solution (10 mL), toluene 30 mL, ethanol 10 mL And the mixture was stirred under reflux for 12 hours. After the reaction was completed, 50 mL of H2O was added, and the mixture was stirred for 3 hours. The mixture was filtered under reduced pressure, separated by column chromatography using methylene chloride (MC) and methanol as an eluent, EN-145-1 (5.56 g, yield 75.6%).
With the rapid development of chemical substances, we look forward to future research findings about 58536-46-2.
Reference:
Patent; LG Display Co., Ltd.; Shin Ji-cheol; Joo Seong-hun; Ryu Seon-geun; Yoon Seung-hui; (44 pag.)KR2018/67321; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia