Adding a certain compound to certain chemical reactions, such as: 58536-46-2, 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C22H15BrN2, blongs to pyrimidines compound. COA of Formula: C22H15BrN2
Synthesis of Intermediate GIn a 500 ml three necked round bottom flask, 38.7 g (100 mmol) of 4-(4-bromophenyl)-2,6-diphenylpyrimidine, 2.7 g (3 mmol) of Pd2(dba)3,2.21 g (6 mmol) tricyclohexylphosphine,55.9 g (220 mmol) of bis (pinacorate) diborane and 39.25 g (400 mmol) of potassium acetate put it in nitrogen,300 ml of 1,4-dioxane was added and stirred for 4 hours at reflux.After completion of the reaction, the mixture was extracted with Methylene Chloride, the organic layer was dried with MgSO4, purified by column chromatography, and crystallized with n-Hexane to give 36 g (82.9.%) As intermediate G.
The synthetic route of 58536-46-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jinung Industry Co., Ltd.; Lee Eung; Lee Jong-ryun; Cho Eun-sang; Lee Ji-hwan; Kuk Chang-hun; (29 pag.)KR102052332; (2019); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia