Application of 205672-25-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 205672-25-9, name is 4-Amino-5-bromo-2-chloropyrimidine. A new synthetic method of this compound is introduced below.
1 L reaction flask was charged with 20.8 g (0.1 mol) of Compound I and 208 mL of tetrahydrofuran,After stirring and dissolving,The system was cooled to -78 C. After the temperature was stabilized, 62.5 mL of n-butyllithium-n-hexane (15% concentration) was added dropwise. A solution of 12.9 g (0.125 mol) of N-methoxy-N-methylacetamide and 129 mL of tetrahydrofuran was added dropwise while maintaining the temperature for 10 min. After stirring for 1 h, the system was warmed to 0 C and 100 mL of saturated ammonium chloride solution was added. After stirring for 30 min, the mixture was extracted with 3X 300 mL of ethyl acetate. The organic layers were combined and the organic layer was washed with 3X 300 mL of saturated brine and dried over anhydrous magnesium sulfate Dried, filtered and concentrated to give 15.8 g of crude yellow solid, yield: 91.9%, used directly in the next step.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,205672-25-9, 4-Amino-5-bromo-2-chloropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Jiangsu Zhongbang Pharmaceutical Co., Ltd.; Han Xiaojun; Huang Shuang; Qian Gang; Liu Liping; Sheng Zecui; (9 pag.)CN105153149; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia