With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1159818-57-1, name is 4-Amino-6-bromopyrimidine, molecular formula is C4H4BrN3, molecular weight is 173.9987, as common compound, the synthetic route is as follows.Application In Synthesis of 4-Amino-6-bromopyrimidine
6-bromopyrimidine-4-amine (1.01 g, 5.80 mmol)And an aqueous ammonia solution (25 mL) was placed in a sealed tube.The mixture was stirred at 125 C overnight.Then cool to room temperature,It was concentrated under reduced pressure.The residue obtained was purified by silica gel column chromatography (MeOH/DCM (v/v)=1/15).The title compound was obtained as a yellow solid (0.46 g, yield 72%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1159818-57-1, 4-Amino-6-bromopyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Peng Ju; Li Xiaobo; Zhang Tao; Hu Haiyang; Chen Wuhong; Bai Changlin; Ke Donghua; Chen Peng; (217 pag.)CN109776522; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia