In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 74840-34-9, name is 4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid, the common compound, a new synthetic route is introduced below. Product Details of 74840-34-9
Preparation of Compound II:4-chloro2-methylthiopyrimidine-5-formic acidI (25.60g, 0.12mol)Suspended in 100 mL of tetrahydrofuran,Add oxalyl chloride (16.67 g, 0.13 mol),Add 2 drops of DMF,Stir at 35 degrees for 1 hour,Add to the reaction solution23mL 22percent ammonia solution,Stir for 15 hours under 15 degrees.An off-white solid precipitates, suction filtration,The filter cake was washed twice with 10 mL of water.After the filter cake is dried by phosphorus pentoxide,Obtained 25.21 g of a white solid compound II,The yield was 98.94percent.
The synthetic route of 74840-34-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tierxi (Nanjing) Pharmaceutical Research And Development Co., Ltd.; Wu Wenchao; Song Dandan; Zhang Chi; Cui Xilin; (10 pag.)CN110117274; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia