Synthetic Route of 4318-56-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4318-56-3, name is 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows.
7.71 g of 2-cyanobenzyl bromide (R1 is H and R2 is Br), 6.00 g of 3-methyl-6-chlorouracil and 4.20 g of triethylamine were dissolved in a mixed solution of 78 ml of DMSO and THF, and the temperature was raised The reaction was stirred at 50 C for 1 h, and the reaction was cooled to room temperature. 80 ml of ice water was slowly added dropwise, and the mixture was stirred for 1 h under ice-cooling. The crude product of compound III was 9.15 g. The yield was 88.81%. The crude compound III was rinsed with ethyl acetate at 25 C, filtered, washed and dried to give pure Compound III 8.94. The purification yield was 97.90%. The total yield of compound was 86.77% and the purity was 89.70%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4318-56-3, 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione.
Reference:
Patent; Beijing Wansheng Pharmaceutical Co., Ltd.; Lin Guoliang; Wang Qiang; Jiang Yugang; Wang Yiping; Kang Yi; Lv Xiaona; (10 pag.)CN106608853; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia