In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4359-87-9, name is 2,4,6-Trichloro-5-nitropyrimidine, the common compound, a new synthetic route is introduced below. COA of Formula: C4Cl3N3O2
To a stirred suspension of K-1 (1.00 g, 4.38 mmol) and DIEA (1.83 mL, 10.51 mmol) in DCM (15 mL) at 0 C is slowly added K-2 (1.00 g, 9.30 mmol) and the reaction is allowed to slowly warm to 25 C and stirred for 4h. The volatiles are removed under reduced pressure and the resulting residue is purified by Si02 flash chromatography to yield K-3.
The synthetic route of 4359-87-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BRUNETTE, Steven Richard; CSENGERY, Johanna; HUGHES, Robert Owen; LI, Xiang; SIBLEY, Robert; TURNER, Michael Robert; XIONG, Zhaoming; (88 pag.)WO2017/58831; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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