Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4472-45-1, name is 4-Chloro-2,6-dimethylpyrimidine. A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Chloro-2,6-dimethylpyrimidine
2,4-Dimethylpyrimidine-6-d (12-6-d). To a suspension of 6-chloro-2,4-dimethylpyrimidine (0.40 g, 2.8 mmol),sodium carbonate (1.50 g), 10% Pd-C (0.30 g) in methanol-d (20 mL) was passed D2 (g) for 4 hours. Kugelrohr distillation (100 oC, 1 mmHg) gave the title compound 12-6-d as a colorless liquid (0.27 g, 87%); 1H NMR (CDCl3) 2.50 (s, 3H), 2.60 (s, 3H) 7.40 (s, 1H), 8.40 (residual proton at C-6 (d, J 5.1 Hz); 13C NMR (CDCl3) 24.1 (CH3),24.7 (CH3), 118.0 (C-5), 156.9 (C-6, t, J 26.8 Hz), 167.3 (C-4), 168.2 (C-2).
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Reference:
Article; Pavlik, James W.; Vongakorn, Tharinee; Kebede, Naod; Arkivoc; vol. 2017; 5; (2017); p. 216 – 228;,
Pyrimidine | C4H4N2 – PubChem,
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