Some tips on 5-Aminopyrimidine-2,4(1H,3H)-dione

At the same time, in my other blogs, there are other synthetic methods of this type of compound,932-52-5, 5-Aminopyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.932-52-5, name is 5-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, molecular weight is 127.1014, as common compound, the synthetic route is as follows.COA of Formula: C4H5N3O2

Intermediate 4: 6-Methylpyridor3,2-c/lpyrirnidine-2,4(1H,3H)-dione; A mixture of 5-aminouracil (3 g; 23.6 mmol; 1 eq.) and crotonaldehyde (2.04 ml 24.8 mmol; 1.05 eq.) in 20% HCI (20 ml.) was stirred at 1 100C for 1 hour. The solution was evaporated in vacuo and the residue precipitated from EtOH to afford the title compound as a black solid. 1H NMR (300 MHz, DMSO-d6) delta 8.90-8.50 (m, 2H), 7.80 (d, 1 H), 7.51 (d, 1 H), 2.50 (s, 3H). MS (ES+): 178.1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,932-52-5, 5-Aminopyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SERONO S.A.; POMEL, Vincent; GAILLARD, Pascale; DESFORGES, Gwenaelle; QUATTROPANI, Anna; MONTAGNE, Cyril; WO2010/37765; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia