In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22276-95-5, name is 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C6H3BrClN3
To a solution of 5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (obtained in Reference Example 8(1); 2.00 g) in tetrahydrofuran (50 mL) was added dropwise under nitrogen atmosphere at -65C 2.64M butyllithium-hexane solution (7.2 mL), and then the mixture was stirred for 30 minutes. To the reaction mixture was added a solution of ethyl chloroformate (905 muL) in tetrahydrofuran (5 mL), and the mixture was stirred at room temperature overnight. To the reaction mixture was added a saturated aqueous ammonium chloride solution, and then the mixture was extracted with ethyl acetate. The organic layer was dried over magnesium sulfate and then filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by column chromatography on silica gel (solvent; hexane/ethyl acetate = 65/35 to 20/80) to give 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid ethyl ester (1.43 g) as a colorless solid (yield: 74%). MS(APCI)m/z; 226/228[M+H]+.
The synthetic route of 22276-95-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2390254; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia