Reference of 56181-39-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56181-39-6, name is 5-Bromo-4-chloropyrimidine, molecular formula is C4H2BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Compound (III-11) (120 mg, 0.620 mmol) and compound (IIb-2) (150 mg, 0.931 mmol) were dissolved in NMP(2.0 mL), p-toluenesulfonic acid monohydrate (118 mg, 0.620 mmol) was added and the mixture was stirred at 60C for2 hr. The reaction mixture was allowed to cool, water was added, and the mixture was extracted with ethyl acetate. Theorganic layer was dried over anhydrous sodium sulfate, and filtered. The solvent was evaporated under reduced pressure,and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate) to give compound (IV-122)(yield 100 mg, 51%)
According to the analysis of related databases, 56181-39-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; WATANABE, Atsushi; SATO, Yuuki; OGURA, Keiji; TATSUMI, Yoshiyuki; (331 pag.)EP3351533; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia