Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7752-82-1, name is 5-Bromopyrimidin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C4H4BrN3
To a solution of 45 (5.0 g, 28.7 mmol) in THF (50 mL) are added di-tert-butyi dicarbonate (13.8 g, 63.2 rnrnoi), TEA (12.0 rnL, 86 mmol), and DMAP (360mg, 2.87 mmol). After stirring at 60 C for 16 hour, the mixture is concentrated and purified by silica gel column chromatography (EA:PE = 1:5) to give 46 as a while solid (9.0 g, 84% yield). (MS: [M+HI 374.1)
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Reference:
Patent; IMMUNE SENSOR, LLC; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; ZHONG, Boyu; SUN, Lijun; SHI, Heping; LI, Jing; CHEN, Chuo; CHEN, Zhijian; (270 pag.)WO2017/176812; (2017); A1;,
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