Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56844-12-3, name is 6-Bromo-4-chlorothieno[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below., Quality Control of 6-Bromo-4-chlorothieno[2,3-d]pyrimidine
General procedure: Compound 4 (202 mg, 0.811 mmol) was mixed with phenylboronic acid (5a) (249 mg, 2.04 mmol, 2.5 equiv), finely powdered K2CO3 (341 mg, 2.47 mmol), Pd(PPh3)4 (47 mg, 0.040 mmol), 1,4-dioxane (2 mL) and water (2 mL). The reaction was then stirred at 110 C for 3 h. The solvent was removed and the residue was dissolved in EtOAc (25 mL) and washed with water (3×15 mL). The organic phase was dried over Na2SO4, filtered and evaporated onto silica gel. The obtained material was purified by silica gel column chromatography (n-pentane/EtOAc, 3/1).
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Reference:
Article; Bugge, Steffen; Kaspersen, Svein Jacob; Sundby, Eirik; Hoff, Bard Helge; Tetrahedron; vol. 68; 45; (2012); p. 9226 – 9233;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia