Synthetic Route of 13479-88-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13479-88-4, name is 5,7-Dichlorothiazolo[5,4-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: Example 6. General Procedure F A mixture of the desired chlorothiazolopyrimidines i-F (1 equiv), desired aminomethyl heterocycle or benzylamine ii-F (1.1 equiv), and triethylamine (NEt3) (1.5 equiv) in 1,4-dioxane (~0.1 M) was stirred at room temperature until the reaction was complete by LC-MS and/or TLC analysis. The reaction mixture was concentrated to dryness then re-dissolved in CH2Cl2 and washed with saturated NaHCO3 solution. The organic extract was dried over Na2SO4, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (typical eluents included, for example, a mixture of hexanes and EtOAc, or a mixture of CH2Cl2 and MeOH, or an 80:18:2 mixture of CH2Cl2/CH3OH/concentrated NH4OH) to afford the desired product iii-F. The product structures prepared according to General Procedure F were confirmed by 1H NMR and/or by mass analysis.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13479-88-4, 5,7-Dichlorothiazolo[5,4-d]pyrimidine.
Reference:
Patent; THE GENERAL HOSPITAL CORPORATION; UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES; SLAUGENHAUPT, Susan, A.; JOHNSON, Graham; PAQUETTE, William, D.; ZHANG, Wei; MARUGAN, Juan; (306 pag.)WO2016/115434; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia