Reference of 63200-54-4, Adding some certain compound to certain chemical reactions, such as: 63200-54-4, name is 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine,molecular formula is C6H3Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63200-54-4.
Step 1: preparation of 2,4-dichloro-5-(3-methoxylpropyl)-5H-pyrrolo[3,2-d]pyrimidine 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine (188 mg, 1.0 mmol) and sodium hydride (45 mg, 1.5 mmol) were dissolved in N,N-dimethylformamide (5 mL). The reaction mixture was stirred at room temperature for 1 hour, followed by adding 1-bromo-3-methoxypropane (184 mg, 1.2 mmol). The solution was stirred overnight at room temperature. The reaction mixture was diluted with ethyl acetate (20 mL) and washed with brine. The organic phase was dried over anhydrous sodium sulfate and separated by flash column chromatography (eluent: n-hexane: ethyl acetate = 2: 1) to give 200 mg of a white solid. Yield: 77%. MS (ESI, m/z): [M+H]+: 260.1.
According to the analysis of related databases, 63200-54-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Beijing Hanmi Pharmaceutical Co., Ltd.; XUE, Baoyu; ZHENG, Runa; CHA, Mi Young; KIM, Maengsup; (71 pag.)EP3336091; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia