Electric Literature of 67831-83-8 ,Some common heterocyclic compound, 67831-83-8, molecular formula is C7H7N3OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of (35m) (1.0 g, 5.5 mmol) in POCI3 (10 mL) cooled at 5C on an ice bath was added dropwise diethylaniline (1.0 mL, 6.2 mmol). After 2 hours stirring at 80C, the mixture was poured on crushed ice and the resulting precipitate was filtered off and purified by silica gel column chromatography.Yield: 33%.Melting point: 206-208C.H NMR (DMSO -d6) d 2.56 (s, 3H, S CH3), 6.52 (s, 1H, 5 -H), 7.52 (s, 1H, 6 -H), 12.39 (s, 1H, N H). 13C NM R (DMSO -d6) d 13.8 (SCH3), 99.0 (C-5), 113.2 (C-4a), 126.9 (C-6), 150.4-152.7 (C-4/C-7a),162.7 (C-2).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 67831-83-8, 2-(Methylthio)-7H-pyrrolo[2,3-d]pyrimidin-4-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UNIVERSITE DE LIEGE; LANCELLOTTI, Patrizio; OURY, Cecile; PIROTTE, Bernard; (140 pag.)WO2019/158655; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia