Adding a certain compound to certain chemical reactions, such as: 7752-72-9, 5-Chloro-6-methylpyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Chloro-6-methylpyrimidin-4(3H)-one, blongs to pyrimidines compound. Application In Synthesis of 5-Chloro-6-methylpyrimidin-4(3H)-one
2) The Preparation of Intermediate 4,5-dichloro-6-methylpyrimidine 50 ml of POCl3 was added dropwise to a solution of 14.5 g (0.1 mol) of 4-hydroxyl-5-chloro-6-methylpyrimidine in 50 mL of toluene, the mixture was refluxed for 5-7 h after addition. After the reaction was over by Thin-Layer Chromatography monitoring, the reaction mixture was concentrated under reduced pressure to remove toluene and extra POCl3, and then poured into ice water. The water phase was extracted with ethyl acetate (3*50 ml), the organic phases were emerged, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was purified through silica column to give 14.43 g as yellow liquid with yield of 88.5%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,7752-72-9, 5-Chloro-6-methylpyrimidin-4(3H)-one, and friends who are interested can also refer to it.
Reference:
Patent; SINOCHEM CORPORATION; Liu, Changling; Guan, Aiying; Lan, Jie; Wang, Lizeng; Wang, Bin; Zhu, Minna; Sun, Qin; Ren, Weijing; Feng, Cong; Ren, Lanhui; Chai, Baoshan; Li, Zhinian; US2015/225378; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia