Application of 41103-17-7, Adding some certain compound to certain chemical reactions, such as: 41103-17-7, name is Ethyl 4-chloropyrimidine-5-carboxylate,molecular formula is C7H7ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41103-17-7.
To a solution of ethyl 4-chloropyrimidine-5-carboxylate (10.5g, 0.056mol) was dissolved in DMF (lOOmL) was added 2-isopropyl-lH-imidazole (6.2g, 0.056mol) and Cs2C03 (27.6g), and then heated to 80C for lhrs, showed reaction completed). After cooled to r.t., water (500 mL) was added, then extracted with EA (200 mL* 2), washed with brine and dried over Na2S04. Then concentrated under reduced pressure and purified by flash chromatography on silica gel column (elution: PE/EA=3/1) to giveExample 43a (9.7 g, yield 66%) as a yellow solid. LCMS [M+1] =261
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 41103-17-7, Ethyl 4-chloropyrimidine-5-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (212 pag.)WO2017/218960; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia