The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111196-81-7, name is 2-Chloro-5-ethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Chloro-5-ethylpyrimidine
General procedure: Add in the reaction bottleBoc-based disubstituted pyrimidopyrimidine (50 mg, 0.09 mmol),2-chloro-5-ethylpyrimidine (18 mg, 0.13 mmol),TEA (27 mg, 0.45 mmol) and DCM (2 mL).The reaction was stirred at room temperature overnight, and the reaction mixture was diluted with dichloromethane.The organic phase was washed with brine, dried over anhydrous sodiumThe crude product using silica gel column chromatography (petroleum ether: ethyl acetate = 1: 1) to give a pale yellow solid, yield 45% reaction.
With the rapid development of chemical substances, we look forward to future research findings about 111196-81-7.
Reference:
Patent; Jiangxi University of Traditional Chinese Medicine; Yang Zunhua; Fang Yuanying; Liu Ronghua; He Mingzhen; Wang Qi; Li Zhifeng; (13 pag.)CN109761990; (2019); A;,
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