Adding a certain compound to certain chemical reactions, such as: 6554-61-6, 4,5-Dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4,5-Dichloropyrimidine, blongs to pyrimidines compound. Safety of 4,5-Dichloropyrimidine
A solution of 4,5-dichloropyrimidine (0.15 mL, 1.5 mmol) and 2-((pyridin-2-ylmethyl)thio)-1 /-/- benzo[d]imidazole R (300 mg, 1.24 mmol) in dry DMF (1.5 mL) was treated with a 60% mineral oil dispersion of sodium hydride (55 mg, 1.4 mmol), stirred at RT for 5 min then heated to 70C for 90 min. The mixture was treated with saturated aqueous ammonium chloride solution (2 mL), diluted with EtOAc (40 mL), washed with water (3 x 40 mL) and brine, dried (MgSCU) and chromatographed on a basic silica column eluting with 0-100% EtOAc / PE. The product was purified further by mass-directed prep. HPLC eluting with MeCN-H20 to give 1-(5-chloropyrimidin-4-yl)-2-((pyridin-2-ylmethyl)thio)-1 /-/- benzo[d]imidazole 59 (22 mg, 5%) as a pale orange gum. 1H NMR (500 MHz, CDC) delta 9.15 (s, 1H), 8.96 (s, 1H), 8.52 (d, J = 4.3 Hz, 1H), 7.76 (d, J = 8.0 Hz, 1H), 7.60 (td, J = 7.7, 1.8 Hz, 1H), 7.47 (d, J = 7.8 Hz, 1H), 7.36-7.29 (m, 1H), 7.25- 7.20 (m, 1H), 7.16 (dd, J = 6.8, 5.0 Hz, 1H), 7.05 (d, J = 8.0 Hz, 1H), 4.77 (s, 2H); LCMS (method B): 2.23 min (354.2, MH+).
The synthetic route of 6554-61-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; REDAG CROP PROTECTION LTD; URCH, Christopher, John; BUTLIN, Roger, John; CHRISTOU, Stephania; BOOTH, Rebecca, Kathryn; (111 pag.)WO2018/130838; (2018); A1;,
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