Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60025-09-4, name is 4-Amino-6-chloropyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 60025-09-4
To a solution of (S)-6-amino-1′,8-dimethyl-2H-spiro[imidazo[1,5-a]pyridine-3,3′-piperidine]-1,5-dione (6B, 2.0 g, 7.6 mmol) in tert-butanol (30 mL) were added 4-amino-6-chloropyrimidine-5-carbonitrile (7, 1.17 g, 7.6 mmol) and p-toluenesulfonic acid (1.30 g, 7.6 mmol). The reaction mixture was heated at 120 C. for 15 h in a sealed tube. Then the reaction mixture was concentrated and the residue was dissolved in 20% isopropanol/chloroform (100 mL). The organic layer was washed with a solution of saturated sodium bicarbonate solution, dried over sodium sulphate, filtered and concentrated. The residue was purified with silica gel column chromatography using combiflash (5-7% methanol in dichloromethane) to afford (S)-4-amino-6-((1′,8-dimethyl-1,5-dioxo-1,5-dihydro-2H-spiro[imidazo[1,5-a]pyridine-3,3′-piperidin]-6-yl)amino)pyrimidine-5-carbonitrile (Cpd. No. 2Fb) as a white solid. Yield: 0.49 g, 18%. MS (ESI) m/z 381.17[M+1]+; ee=95.58%, Rt=8.89 min, Chiralpak IC (4.6*250 mm, 5 mum) using an isocratic gradient of methanol/carbon dioxide (40:60).
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Reference:
Patent; eFFECTOR Therapeutics, Inc.; ERNST, Justin T.; SPRENGELER, Paul A.; REICH, Siegfried H.; SPERRY, Samuel; US2018/228803; (2018); A1;,
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