The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Application In Synthesis of 4595-59-9.
Song, Geyang;Yang, Liu;Li, Jing-Sheng;Tang, Wei-Jun;Zhang, Wei;Cao, Rui;Wang, Chao;Xiao, Jianliang;Xue, Dong research published 《 Chiral Arylated Amines via C-N Coupling of Chiral Amines with Aryl Bromides Promoted by Light》, the research content is summarized as follows. A method based on mol. Ni catalysis driven by light, which enabled stereoretentive C-N coupling of optically active amines, amino alcs. and amino acid esters with aryl bromides, with no need for any external photosensitizer was reported. The method was effective for a wide variety of coupling partners, including those bearing functional groups sensitive to bases and nucleophiles, thus providing a viable alternative to accessing synthetically important chiral N-aryl amines, amino alcs. and amino acids esters. Its viability was demonstrated by 92 examples with up to 99% ee.
4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., Application In Synthesis of 4595-59-9
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia