In 2022,Song, Peilu; Zhao, Fan; Li, Dahong; Qu, Jiqiang; Yao, Miao; Su, Yuan; Wang, Hanxun; Zhou, Miaomiao; Wang, Yujie; Gao, Yinli; Li, Feng; Zhao, Dongmei; Zhang, Fengjiao; Rao, Yu; Xia, Mingyu; Li, Haitao; Wang, Jian; Cheng, Maosheng published an article in Acta Pharmaceutica Sinica B. The title of the article was 《Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells》.Reference of 2,4-Dichloropyrimidine The author mentioned the following in the article:
The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallog. and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1H-indole derivatives that display high potential and specificity towards group II PAKs. Among these inhibitors, compound 55 exhibited excellent inhibitory activity and kinase selectivity, displayed superior anti-migratory and anti-invasive properties against the lung cancer cell line A549 and the melanoma cell line B16. Compound 55 exhibited potent in vivo antitumor metastatic efficacy, with over 80% and 90% inhibition of lung metastasis in A549 or B16-BL6 lung metastasis models, resp. Further mechanistic studies demonstrated that compound 55 mitigated TGF-β1-induced epithelial-mesenchymal transition (EMT). In the experimental materials used by the author, we found 2,4-Dichloropyrimidine(cas: 3934-20-1Reference of 2,4-Dichloropyrimidine)
2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Reference of 2,4-Dichloropyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia