Adding a certain compound to certain chemical reactions, such as: 108831-66-9, 6-Methyl-3H-thieno[2,3-d]pyrimidin-4-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H6N2OS, blongs to pyrimidines compound. HPLC of Formula: C7H6N2OS
General procedure: A mixture of thienopyrimidinone (0.01 mol), POCl3 (11 mL) and PCl5 (1.5 g) was quickly heated to 105 C and boiled for 5-6 h. The solvent was evaporated. Dry product was dissolved in methylene chloride (12 mL) and neutralized by cold solution of NaOH (0.5 N). The organic phase was separated and dried over Na2SO4, filtered, and then solvent was evaporated in vacuum. The residue was crystallized from isopropyl alcohol. Yield 80%
At the same time, in my other blogs, there are other synthetic methods of this type of compound,108831-66-9, 6-Methyl-3H-thieno[2,3-d]pyrimidin-4-one, and friends who are interested can also refer to it.
Reference:
Article; Ostrynska, Olga V.; Balanda, Anatoliy O.; Bdzhola, Volodymyr G.; Golub, Andriy G.; Kotey, Igor M.; Kukharenko, Olexander P.; Gryshchenko, Andrii A.; Briukhovetska, Nadiia V.; Yarmoluk, Sergiy M.; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 148 – 160;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia