Synthetic Route of 111196-81-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111196-81-7, name is 2-Chloro-5-ethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
3-[(5-Ethyl-pyrimidin-2-yl)-(4-trifluoromethoxy-benzyl)-amino]-propan-1-ol: A solution of 3-(4-trifluoromethoxy-benzylamino)-propan-1-ol (3.1 g, 12.4 mmol), 2-chloro-5-ethylpyrimidine (1.51 mL, 12.4 mmol) and K2CO3 (2.6 g, 18.7 mmol) in DMF (50 mL) was heated to 165 C. overnight in a sealed tube. After cooling to room temperature, the mixture was diluted with ethyl acetate (100 mL) and then washed with water, brine and dried over Na2SO4. After removal of solvent, the residue was purified by silica gel chromatography to give 2.15 g (49%) of the desired product as a colorless solid. 1H NMR (400 MHz, CDCl3) delta 8.18 (s, 2H), 7.26 (d, 2H), 7.13 (d, 2H), 4.83 (s, 2H), 3.71 (t, 2H), 3.52 (t, 2H), 2.48 (q, 2H), 1.73 (m, 2H), 1.20 (t, 3H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 111196-81-7, 2-Chloro-5-ethylpyrimidine.
Reference:
Patent; KALYPSYS, INC; US2007/219193; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia