Electric Literature of 1197953-49-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide. This compound has unique chemical properties. The synthetic route is as follows.
2-[D3]methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline (1.25 g, 4.06 mmol), (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethyl phosphine oxide (the compound of Formula IV) (0.92 g, 2.90 mmol), 14% hydrogenchloride-ethanol (7.5 g, 29 mmol) and ethylene glycol monomethyl ether (22mL) were respectively added in a 35 mLpressure tubing, heated in a microwave to 120C and reacted for 5.5 hours. After the reaction was completed, thereaction solution was cooled down to room temperature and evaporated under reduced pressure to remove the solvent.The residue was dissolved in dichloromethane (60mL) and adjusted to alkaline pH by adding saturated sodium carbonatesolution. The resulting solution was separated. The organic phase was washed with saturated brine (30 mL), dried overanhydrous sodium sulfate, and evaporated under reduced pressure to remove the solvent. The residue obtained wassubjected to silica gel column chromatography (mobile phase, dichloromethane : methanol : triethylamine = 300 : 30 :1.5) to give a crude product. The crude product was beaten with ethyl acetate (10 mL) to give (2-((5-chloro-2-((2-[D3]methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethyl phosphorusoxide (0.18 g, 11.0% yield), with >98% of D3 content.1H-NMR(300 MHz, CDCl3): delta = 10.80 (s, 1H), 8.62 (dd, J = 4.4, 8.2 Hz, 1H), 8.09-8.08 (m, 2H), 7.47 (dd, J = 7.7, 8.0Hz, 1H), 7.31-7.25 (m, 1H), 7.11 (dd, J = 7.4, 7.0 Hz, 1H), 6.54 (s, 1H), 6.48 (dd, J = 1.4, 8.4 Hz, 1H), 3.65 (d, J = 12.2Hz, 2H), 2.73-2.41 (m, 11H), 2.37 (s, 3H), 1.95 (d, J = 11.2 Hz, 2H), 1.85, 1.80 (2s, 6H), 1.73-1.66 (m, 2H).13C-NMR (75 MHz, CDCl3) : delta = 157.76, 155.87, 154.93, 149.29, 147.48, 143.90, 143.87, 132.33, 132.30, 129.52,129.37, 123.10, 123.01, 122.44, 122.27, 122.09, 120.58, 119.55, 108.36, 105.99, 101.01, 61.78, 55.27, 50.46, 48.78,45.83, 28.19, 19.02, 18.08.HRMS (ESI, [M+H]+) m/z: 587.2861.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide.
Reference:
Patent; Chai Tai Tianqing Pharmaceutical Group Co., Ltd.; ZHANG, Yinsheng; LIU, Baomin; YANG, Beibei; (35 pag.)EP3381925; (2018); A1;,
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