Synthetic Route of 13036-57-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13036-57-2, name is 2-Chloro-4-methylpyrimidine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 2-chloro-4-methylpyrimidine (Ig5 7.78mmol) and zinc cyanide (475mg, 4.04mmo) in anhydrous DMF (10ml) was added Pd(PPh3)4 (449mg, 0.366mmol) and nitrogen flushed through the mixture for 5 min. The mixture was heated at 180C for 30 min in a microwave reactor. The reaction was repeated on the same scale and the reaction mixtures were combined. The mixture was partitioned between EtOAc and water (filtered through celite to remove some insolubles), and the organic layer washed with sat. NaCl5 dried over MgStheta4, filtered and evaporated. The residue was purified by MPLC (Biotage Horizon; FLASH 25+M) eluent: 100% Hexanes (90ml), gradient rising from 100% Hexanes to 15% EtOAc in Hexanes (900ml), then 15% EtOAc in Hexanes (500ml) to give Ig of the title compound (54%) as an off- white solid. 1H NMR (CDCl3): 2.62 (s, 3H), 7.42 (d, J 5.1 Hz, 1H)5 8.69 (d, J 5.1 Hz, 1H).
According to the analysis of related databases, 13036-57-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; EDMONDSON, Scott, D.; CHANG, Lehua; KAR, Nam Fung; MORRIELLO, Gregori, J.; MOYES, Christopher, J.; SHEN, Dong-Ming; ZHU, Cheng; ANTHONY, Neville, J.; JONES, Philip; SMITH, Graham, F.; SCOTT, Mark, E.; THOMPSON, Christopher, F.; JUNG, Joon; CAMMARANO, Carolyn; HOFFMAN, Dawn Marie; WO2011/25774; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
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