Synthetic Route of 139756-21-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 139756-21-1, name is 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one, molecular formula is C17H20N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Preparation of intermediate 1-18a: 5-(2-ethoxy-5-iodo-phenyl)-1 -methyl-3- propyl-6H-pyrazolo[4,3-dlpyrimidin-7-one To a solution of intermediate l-09a (10 g, 32 mmol) in TFA (50 mL) was added N-lodosuccinimide (NIS) (8.6 g, 38.4 mmol) at 0 C. The mixture solution was stirred at r.t. overnight. The mixture was quenched with aqueous water and extracted with EtOAc, the organic layer was washed with brine, dried over anhydrous Na2SO4, concentrated to give the crude product which was purified by the column to give the intermediate 1-18a (1 1 g, 79 %) as a white solid. ESI-MS (M+1 ): 439.1 ; calc. for Ci7H19IN4O2: 438.0.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 139756-21-1, 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one.
Reference:
Patent; FUNDACION PARA LA INVESTIGACION MEDICA APLICADA; CUADRADO TEJEDOR, Maria del Mar; GARCIA OSTA, Ana Maria; OYARZABAL SANTAMARINA, Julen; RABAL GRACIA, Maria Obdulia; SANCHEZ ARIAS, Juan Antonio; UGARTE BAZTAN, Ana; (112 pag.)WO2016/20307; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia