Synthetic Route of 145783-15-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 145783-15-9, name is 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, molecular formula is C7H9Cl2N3S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(1) 570g compound II and 2500g water are mixed, then with stirring, add in batches 756g sodium bicarbonate. After completion of addition, while stirring add in batches 350g compound I. Then heat to 100 C. Stir the reaction for 20h, the reaction solution becomes dark red muddy shape, stop heating, cooling to 40 C the following, the reaction product is added to 1000 ml ethyl acetate, stirring 5 min later, the liquid, aqueous phase for the 500 ml ethyl acetate extraction a, combined organic phase, the organic phase by adding 100 ml normal heptane, stirring to wash-out when a large amount of white solid, continue to stir 1h, filtered, get white solid compound III, product after drying 554g, yield of 88.3%, purity of 99.8%;
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 145783-15-9, 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine.
Reference:
Patent; Chengdu Huayu Pharmaceutical Co., Ltd.; Luo, Chaobin; Wan, Jiulei; (7 pag.)CN105669681; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia