As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16357-83-8, name is 4-Aminopyrimidine-5-carbaldehyde, molecular formula is C5H5N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C5H5N3O
General procedure: To a soln. of aldehyde C-3 (1 eq) and amine BB-9 (1 eq) in THF (4 mL/mmol) were added AcOH (2 eq) and the rxn mixture was stirred for 20 min at RT. NaBH(OAc)3 (4 eq) was added portionwise and the rxn mixture was stirred at RT for a given time (see Table 34). When necessary to reach the complete reduction of the intermediate imine, NaBm (1.2 eq) can be added at 0C and the rxn mixture stirred at RT. It was quenched with a 1 M aq. soln. of NaOH and extracted with EtOAc (3x). The combined org. phases were washed with brine, dried over MgSC>4 and concentrated in vacuo. The crude was purified by CC using Hept/EtOAc/MeOH.
With the rapid development of chemical substances, we look forward to future research findings about 16357-83-8.
Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; FROIDEVAUX, Sylvie; HUBLER, Francis; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; (97 pag.)WO2019/141808; (2019); A1;,
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