As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 18592-13-7, name is 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione, molecular formula is C5H5ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 18592-13-7
Referential Example 1 Synthesis of 5-chloro-6-chloromethyluracil To a suspension of 6-chloromethyluracil (163 g) in acetic acid (500 ml), sulfuryl chloride (120 ml) was added dropwise at room temperature over 20 minutes, followed by stirring at the same temperature for 3 hours. The reaction mixture was poured into ice water (500 ml), and a crystallized matter was collected by filtration, whereby 182.3 g of the title compound were obtained (yield: 92%). Melting point: 225 C. min. (decomposed). NMR spectrum (DMSO-d6) delta: 4.46(2H,s), 11.57(1H,s), 11.71(1H,s).
With the rapid development of chemical substances, we look forward to future research findings about 18592-13-7.
Reference:
Patent; Taiho Pharmaceutical Co., Ltd.; US5744475; (1998); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia