With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.905856-70-4, name is 2-Bromo-5-iodopyrimidine, molecular formula is C4H2BrIN2, molecular weight is 284.88, as common compound, the synthetic route is as follows.Quality Control of 2-Bromo-5-iodopyrimidine
5) In a 250 ml three-necked flask, 0.03 mol of intermediate 4-4 was added under nitrogen protection.0.036 mol of 2-bromo-5-iodopyrimidine, 150 ml of toluene, stirred and mixed, and then added 0.045 mol of sodium t-butoxide.0.0015 mol Pd2 (dba) 3, 0.0015 mol of tri-tert-butylphosphine, heated to 115 C with stirring.The reaction was refluxed for 24 hours, and the spot plate was sampled, indicating that no intermediate 4-4 remained, and the reaction was complete;Naturally cooled to room temperature, filtered, and the filtrate was evaporated to dryness under reduced pressure and passed through a neutral silica gel column.Intermediate 4-5 was obtained with HPLC purity of 99.3%, yield 68.9%
At the same time, in my other blogs, there are other synthetic methods of this type of compound,905856-70-4, 2-Bromo-5-iodopyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Tang Dandan; Zhang Zhaochao; Li Chong; Zhang Xiaoqing; (66 pag.)CN108203416; (2018); A;,
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