Related Products of 22536-63-6 , The common heterocyclic compound, 22536-63-6, name is 2-Chloro-4-methoxypyrimidine, molecular formula is C5H5ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2.6 g of 6 (0.018 mol, 1 equiv), 1.3 g of compound 4(0.009 mmol, 0.5 equiv), 1.5 ml of 37% concd HCl (0.018 mol,1 equiv) were added in 10%, aqueous ethanol solution (25 ml)and heated at 80 C for 12 h. After that, the reaction mixturewas cooled to room temperature. The resulting precipitate wasfiltered, washed with mixture of water and ethanol, dried in vacuoat 40 C, and the obtained solid was purified by recrystallizationwith a mixture of water/ethanol to afford 2.3 g productas a white solid with the yield of 49%. Mp: 182-184 C, 1HNMR (400 MHz, DMSO-d6) d ppm: 3.93 (s, 3H, -OCH3), 6.29 (d,1H, J = 5.6 Hz, Pyrm-H), 7.14-7.19 (m, 2H, Ph-H), 7.60 (d, 1H,J = 1.2 Hz, Ph-H); 8.20 (d, 1H, J = 5.6 Hz, Pyrm-H), 9.55 (s, 1H,OH), 10.00 (s, 1H, NH); 13C NMR (100 MHz, DMSO-d6) d ppm:53.99 (-OCH3), 99.10, 107.53, 111.46, 112.37, 129.67, 140.74,153.22, 158.73, 160.04, 169.92; ESI-MS: 252.3 [M+H]+, 254.1[M+3]+, 274.6 [M+Na]+. C11H10ClN3O2 [251.67].
The synthetic route of 22536-63-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Rai, Diwakar; Chen, Wenmin; Tian, Ye; Chen, Xuwang; Zhan, Peng; De Clercq, Erik; Pannecouque, Christophe; Balzarini, Jan; Liu, Xinyong; Bioorganic and Medicinal Chemistry; vol. 21; 23; (2013); p. 7398 – 7405;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia