Application of 22536-61-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.22536-61-4, name is 2-Chloro-5-methylpyrimidine, molecular formula is C5H5ClN2, molecular weight is 128.56, as common compound, the synthetic route is as follows.
NBS (0.28g, 1.56mmol) and AIBN (0.05g, 0.31mmol) were added to a solution of Example 52C (0.2g, 1.56mmol)in carbon tetrachloride (10mL) and the mixture was stirred at 80C for 12 hours. Water was added and the aqueouslayer was extracted with dichloromethane. The organic layer was purified by preparative TLC (ethyl acetate) to give thetitle compound (40mg), LCMS (ESI) m/z: 206 [M+1]+.
Statistics shows that 22536-61-4 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-5-methylpyrimidine.
Reference:
Patent; Harbin Zhenbao Pharmaceutical Co., Ltd.; Medshine Discovery Inc.; CHEN, Shuhui; CHEN, Zhengxia; DAI, Meibi; XIE, Cheng; LI, Peng; ZHANG, Yang; LIANG, Guibai; WANG, Qiang; LIAO, Jiangpeng; SUN, Fei; HU, Guoping; LI, Jian; (166 pag.)EP3333157; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
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