Application of 87591-84-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 87591-84-2, name is 2-(Chloromethyl)-8-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, molecular formula is C10H9ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[0400] To a solution of I -(2-methoxyphenyl)-5-(thiophen-2-yl)- 1 H-imidazole-2-thiol (50.0 mg, 0.17 mmol) in acetone (2 mL) was added 2-(chloromethyl)-8-methyl-4H- pyrido[l,2-a]pyrimidin-4-one (40 mg, 0.19 mmol) and K2C03 (71 rng, 0.51 mmol). Then the mixture was warmed to 60 C and stirred until the reaction was completed (2hrs). Aftet cooling to room temperature, the reactant was filtered and the filtrate was concentrated to dryness in vacuum. The residue was diluted with EA (5 rnL) and the suspension was washed with aqueous 5% NaOH (5 mL), brine (5 mL). The organic layer was dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by Prep-TLC (PE/EA = 1/1) to give 2-[ I -(2-methoxy-phenyl)-5-thiophen-2-yl- I H-imidazol-2-ylsu lfanylmethyl]-7-methyl- pyrido[1,2-a]pyrimidin-4-one (20 mg, yield: 25%) as a yellow solid. [0401] ?HNMR (300 MHz, DMSO-d6): = 8.77 (s, 1H), 7.85 (dd, J= 9.0 Hz, 1.8 Hz,IH), 7.61-7.48 (m, 2H), 7.39 (s, lH), 7.36 (dd, J 8.0 Hz, 1.1 Hz, 1H), 7.27-7.16 (in, 2H),7.00 (t, 1=7.5 Hz, lH), 6.92 (dd, J 5.0 Hz, 3.8 Hz, lH), 6.80 (dd, J 5.0 Hz, 1.1 Hz, IH),6.34 (s, IH), 4.21 (s, 2H), 3.66 (s, 3H), 2.39 (s, 3H). MS: m/z 461.1 ( M+H).
According to the analysis of related databases, 87591-84-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; PINKERTON, Anthony, B.; SMITH, Layton, H.; (113 pag.)WO2015/184011; (2015); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia