Reference of 149849-92-3 ,Some common heterocyclic compound, 149849-92-3, molecular formula is C5H3ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Buildin block A9: 2-lsopropoxy-pyrimidine-4-carboxylic acid2-Chloropyrimidine-4-carboxylic acid (100 mg, 0.63 mmol) was dissolved in 1-propanol (3 ml) and sodium hydride (55-65%, 63 mg, 1.58 mmol) was added carefully in portions. The mixture was heated for 1 h at 150C in a microwave oven. The mixture was poured on ice- water and the mixture was acidified to pH 3. Extraction with DCM, drying over sodium sulfate and evaporation of the solvent under reduced pressure gave the product as a solid (78 mg, 68%). [1 H-NMR (DMSO, 400 MHz) 8.80 (d, 1 H), 7.53 (d, 1 H), 5.24 (hep, 1 H), 1.32 (d, 6H); LCMS RtD = 2.739 min; [M+H]+ = 183.0]
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,149849-92-3, its application will become more common.
Reference:
Patent; NOVARTIS AG; BETSCHART, Claudia; COTESTA, Simona; HINTERMANN, Samuel; WAGNER, Juergen; ROY, Bernard, Lucien; GERSPACHER, Marc; VON MATT, Anette; BEHNKE, Dirk; WO2011/73316; (2011); A1;,
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