Electric Literature of 149849-92-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.149849-92-3, name is 2-Chloropyrimidine-4-carboxylic acid, molecular formula is C5H3ClN2O2, molecular weight is 158.54, as common compound, the synthetic route is as follows.
Under nitrogen protection, 2-chloro-4-pyrimidinecarboxylic acid (16 mg, 0.10 mmol) was charged.4-(8-Amino-3-((1R,3S,4S)-2-azabicyclo[2.2.1]heptan-3-yl)imidazo[1,5-a]pyrazin-1-yl -N-(pyridin-2-yl)benzamide (43 mg, 0.10 mmol) and TEA (20 mg, 0.20 mmol) in 1 mL THFHBTU (57 mg, 0.15 mmol), the reaction mixture was stirred at room temperature overnight.After TLC showed that the reaction of the starting material was complete, the reaction was quenched with water and extracted with EA (5 mL×3).The organic phase was back-washed with saturated brine, dried over anhydrous Na 2SO 21mg of target compound,It is a yellow solid.
The chemical industry reduces the impact on the environment during synthesis 149849-92-3, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Chengdu Beite Pharmaceutical Co., Ltd.; Chengdu Hai Borui Pharmaceutical Co., Ltd.; Li Yingfu; Huang Haoxi; Liu Guanfeng; Chen Tonghun; Ren Junfeng; Yi Shoubing; Su Zhonghai; (49 pag.)CN108191871; (2018); A;,
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