With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.42839-09-8, name is 2-Pyrimidinemethanol, molecular formula is C5H6N2O, molecular weight is 110.11, as common compound, the synthetic route is as follows.Product Details of 42839-09-8
Preparation of i-2a; Step A: Preparation of pyrimidin-2-ylmethyl methanesulfonate (i-2a); Methanesulfonyl chloride (4.40 mL, 57.1 mmol) was added to a stirred solution of2-hydroxymethylpyrimidine (6.28 g, 57.1 mmol) and triethylamine (9.50 mL, 68.5 mmol) in DCM (250 mL) at 00C. After approximately 20 min, the reaction mixture was poured into water, the organic layer was separated and the aqueous phase was re-extracted twice with DCM. The combined organic extracts were washed with water, brine, dried (sodium sulfate), and concentrated in vacuo to afford the title compound i-2a. 1HNMR (500 MHz, CDCl3): delta 8.81 (d,2H, J= 4.8 Hz), 7.32 (t, IH, J= 4.9 Hz), 5.46 (s, 2H), 3.24 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,42839-09-8, 2-Pyrimidinemethanol, and friends who are interested can also refer to it.
Reference:
Patent; MERCK & CO., INC.; WO2007/120574; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia