Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 211244-81-4, name is 2-(Methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one. A new synthetic method of this compound is introduced below., Recommanded Product: 2-(Methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one
Example 30 2-Methanesulfinyl-8H-pyrido[2,3-d]pyrimidin-7-one To a room temperature solution of 2-methanesulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one (120 mg, 0.62 mmol) in 20 mL of chloroform was added (+-)-trans-2-(phenylsulfonyl)-3-phenyloxaziridine (200 mg, 0.77 mmol). The solution was stirred at room temperature overnight. The solid was collected by filtration and found to be 2-methylthio-8H-pyrido[2,3-d]pyrimidin-7-one. The filtrate was stirred at room temperature for 2 days then concentrated. Addition of ethyl acetate resulted in the formation of a solid that was collected by filtration to provide 64 mg (76% based on recovered starting material) of 2-methanesulfinyl-8H-pyrido[2,3-d]pyrimidin-7-one, mp 237-242 C. Analysis calculated for C8H7N3O2S-0.2H2O: C, 45.15; H, 3.50; N, 19.74. Found: C, 45.41; H, 3.23; N, 19.80.
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Reference:
Patent; Warner-Lambert Company; US6498163; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia